Research programme: Assessment technology

This research programme uses the conceptual framework on neurogenic inflammation and central sensitisation. We aim to develop assessment instruments that can be used to measure centrain aspects in CRPS in both healthy patients as well as CRPS patients. Some of the techniques for these purposes are already available in one or more of the participating centres. Measures that can be derived from these techniques are evaluated for their reliability, validity and sensitivity to change.

To illustrate the types of measurements we focus on, we present a few examples:
• Thermography: to measure differences in temperature between the affected and the non-affected limbs;
• movement velocity;
• Typical patterns in reflexes and regulating mechanisms;
• Volumes of extremities affected by CRPS to measure swellings.

Co-ordination
The co-ordinators of this research programma are Prof. Dr. Frans van der Helm en Dr. Ir. Alfred Schouten (both DUT).

Co-operation with private companies
Two private companies are participating in the TREND consortium: Noldus Information Technology and Moog-FCS Control Systems. Several instruments are under construction, starting with prototypes that are refined during the research process. The instruments are developed for use in neurological departments in hospitals, and should be operated by clinical neurophysiological laborants.

Thermography
Below you see an example of thermographic image of a patient with warm CRPS. Notice the difference between the healthy hand (left) and the hand affected by CRPS (right).

De Catwalk
In co-operation with Noldus Information Technology the CatWalk has been developed. This system dynamically measures
footprints of a rat or mouse on basis of which locomotor deficits and pain syndromes can be assessed. See the picture below for an example of a rat’s footprints on the CatWalk.

More information on the CatWalk can be found on www.noldus.com or in product leaflet (pdf).

PoPe/Wristalyzer
Together with Moog-FCS Control Systems TREND has been working on the development of the Wristalyzer (picture below), an instrument to compare movement patterns of CRPS patients with healthy controls.

For more information please check the Moog-FCS website.