TREND (Trauma RElated Neuronal Dysfunction) is a consortium of Dutch medical and technical universities and industrial companies, in which the research on Complex Regional Pain Syndrome type 1 (CRPS-1) is integrated.

Publications

On this page you find an overview of TREND publications. You can also download the full text articles if you have access to Pubmed or the databases of the journals.

2010

Brunner F, Heitz C, Kissling R, Kessels AG, Perez RS, Marinus J, Ter Riet G, Bachmann LM. German translation and external validation of the Radboud Skills Questionnaire in patients suffering from Complex Regional Pain Syndrome 1. BMC
Musculoskelet Disord. 2010 Jun 1;11(1):107. [Abstract / Full text]

de Rooij, A.M.; Gosso, M.F.; Alsina Sanchis, E; Marinus, J.; van Hilten, J.J.; van den Maagdenberg, A.M.J.M. No mutations in the voltage-gated NaV1.7 sodium channel a1 subunit gene SCN9A in Familial Complex Regional Pain Syndrome. European J of Neurology 17:808-814. [Abstract / Full text]

de Rooij AM, Perez RSGM, Huygen FJ, van Eijs F, van Kleef M, Bauer MCR, van Hilten JJ, Marinus J. Spontaneous onset of Complex Regional Pain Syndrome. Eur J Pain 14:510-513.
[Abstract / Full text]

Gosso MF, de Rooij AM, Alsina-Sanchis E, Kamphorst JT, Marinus J, van Hilten JJ, van den Maagdenberg AM. Systematic mutation analysis of seven dystonia genes in complex regional pain syndrome with fixed dystonia. J Neurol 257:820-824. [Abstract / Full text]

Heitz C, Bachmann LM, Leibfried A, Kissling R, Kessels AG, Perez RS, Marinus J, Brunner F. Translating the Dutch Walking Stairs, Walking Ability and Rising and Sitting Questionnaires into German and assessing their concurrent validity with VAS measures of pain and activity in daily living. BMC Musculoskelet Disord. 2010 Jun 1;11(1):108. [Abstract / Full text]

Huehne, Schaal, Leis, Uebe, Gosso, van den Maagdenberg, Maihöfner, Birklein, Rautenstrauss, Winterpacht. Lack of genetic association of Neutral Endopeptidase (NEP) with Complex Regional Pain Syndrome (CRPS). Neuroscience Letters 472:19-23. [Abstract / Full text]

Mugge W, Abbink DA, Schouten AC, Dewald JPA, van der Helm FCT. A rigorous model of reflex function indicates that position and force feedback are flexibly tuned to position and force tasks. Exp Brain Res 200:325-340. [Abstract / Full text]

Munts et al. Efficacy and safety of a single intrathecal methylprednisolone bolus in chronic complex regional pain syndrome. Eur J Pain 14:523-528. [Abstract / Full text]

Perez RSGM, Zollinger PE, Dijkstra PU, Thomassen-Hilgersom IL, Zuurmond WWA, Rosenbrand CJGM, Geertzen JHB. Evidence based guidelines for complex regional pain syndrome type 1. BMC Neurology 10:20. [Abstract / Full text]

Sigtermans M, Noppers I, Sarton E, Bauer M, Mooren R, Olofsen E, Dahan A. An observational study on the effect of S(+)-ketamine on chronic pain versus experimental acute pain in Complex Regional Pain Syndrome type 1 patients. Eur J Pain 14:302-307. [Abstract / Full text]

van Eijs F, Smits H, Geurts J, Kessels A, Kemler M, van Kleef M, Joosten E, Faber C: Brush-evoked allodynia predicts outcome of spinal cord stimulation in Complex Regional Pain Syndrome type 1. Eur J Pain. 2010 Feb;14(2):164-9. [Abstract / Full text]

2009

Boormans EM, Van Kesteren PJ, Perez RSGM, Brölmann HA en Zuurmond WW. Reliability of a Continuous Pain Score Meter: Real Time Pain Measurement. Pain Practice 2009, 9(2): 100-104. [abstract / full text]

Collins S, Zuurmond WW, de Lange JJ, van Hilten BJ, Perez RS. Invravenous Magnesium for Complex Regional Pain Syndrome Type I (CRPS 1) Patients: A Pilot Study. Pain Med 10:930-940.
[abstract / full text]

Gabriel AF, Marcus MAE, Walenkamp GHIM, Joosten EAJ. The CatWalk method: Assessment of mechanical allodynia in experimental chronic pain. Behavioural Brain Research 198:477-480. [abstract / full text]

Groeneweg JG (2009). ‘Cold Case’ Vascular dysregulation in the chronic Complex Regional Pain Syndrome. PhD Thesis. Rotterdam: Erasmus Universiteit.

de Mos M, Huygen FJ, Stricker BH, Dieleman JP, Sturkenboom MC. Estrogens and the risk of complex regional pain syndrome (CRPS). Pharmacoepidemiology and Drug Safety 18:44-52. [abstract / full text]

de Mos M, Huygen FJPM, Stricker BHCh, Dieleman JP, Sturkenboom MCJM. (2009). The association between ACE inhibitors and the complex regional pain syndrome: Suggestions for a neuro-inflammatory pathogenesis of CRPS. Pain 142(3):218-224. [abstract / full text]

de Mos M, Huygen FJPM, Stricker BHCh, Dieleman JP, Sturkenboom MCJM. Referral and treatment patterns for complex regional pain syndrome in the Netherlands. Acta Anaesthesiologica Scandinavica 53:816-825. [Abstract / full text]

de Mos M, Huygen FJPM, van der Hoeven – Borgman M, Dieleman JP, Stricker BHCh, Sturkenboom MCJM. Outcome of the complex regional pain syndrome. The Clinical Journal of Pain, 25:590-597.

de Mos M, Sturkenboom MCJM, Huygen FJPM (2009). Current understandings on complex regional pain syndrome. Pain Practice 9:86-99. [abstract / full text]

Moseley GL, Birklein F, Van Hilten JJ, Marinus J (2009). Reply to: Hall J, Blake D, McCabe C. Inconsistency of response to conscious and unconscious motor imagery in complex regional pain syndrome: comment on the article by Moseley et al. Arthritis & Rheumatism (Arthritis Care & Research), 61:139-142. [abstract / full text]

Mugge W, Schuurmans J, Schouten AC, van der Helm FCT. Sensory weighting of force and position feedback in human motor control tasks. Journal of Neuroscience 29:5476-5482. [abstract / full text]

Munts AG, van der Plas AA, Voormolen JH, Marinus J, Teepe-Twiss IM, Onkenhout W, van Gerven JM, van Hilten JJ. Intrathecal glycine for pain and dystonia in complex regional pain syndrome. Pain 146:199-204. [abstract / full text]

Munts AG, Voormolen JH, Marinus J, Delhaas EM, van Hilten JJ. Postdural puncture headache in complex regional pain syndrome: a retrospective observational study. Pain Med. 10:1469-75.

Ramautar R, van der Plas AA, Nevedomskaya E, Derks R, Somsen GW, de Jong GJ, van Hilten J, Deelder AM, Mayboroda OA. Explorative analysis of urine by capillary electrophoresis-mass spectrometry in chronic patients with complex regional pain syndrome J. Proteome Res 8:5559-67. [Abstract / Full text]

Van Rijn MA, Munts AG, Marinus J, Voormolen JHC, De Boer KS, Teepe-Twiss IM, Van Dasselaar NT, Delhaas EM, Van Hilten JJ. Intrathecal baclofen for dystonia of complex regional pain syndrome. Pain 143:41-47. [abstract / full text]

van Rijn MA, van Hilten JJ, van Dijk JG. Spatiotemporal integration of sensory stimuli in Complex Regional Pain Syndrome and dystonia. J Neural Trans 116:1435-1463. [Abstract / full text]

de Rooij AM, de Mos M, Sturkenboom MC, Marinus J, van den Maagdenberg AM, van Hilten JJ. Familial occurrence of Complex Regional Pain Syndrome. Eur J Pain, 13:171-177. [abstract / full text]

de Rooij AM, de Mos M, van Hilten JJ, Sturkenboom MCJM, Gosso MF, van den Maagdenberg AMJM, Marinus J. Increased risk of Complex Regional Pain Syndrome in siblings of patients? Journal of Pain 10:1250-1255. [Abstract / Full text]

de Rooij AM, Gosso MF, Haasnoot GW, Marinus J, Verduijn W, Claas FHJ, van den Maagdenberg AMJM, van Hilten JJ.HLA-B62 and HLA-DQ8 are associated with Complex Regional Pain Syndrome with fixed dystonia. Pain 145:82-85. [Abstract / full text]

Schuurmans J, de Vlugt E, Schouten AC, Meskers CGM, de Groot JH, van der Helm FCT (2009). The monosynaptic Ia afferent pathway can largely explain the stretch duration effect of the long latency M2 response. Exp Brain Res 193:491-500. [abstract / full text]

Sigtermans MJ, Van Hilten JJ, Bauer MCR, Arbous MS, Marinus J, Sarton EY, Dahan A. Ketamine produces effective and long-term pain relief in patients with Complex Regional Pain Syndrome Type 1. Pain 145:304-311. [Abstract / full text]

Sigtermans MJ, Dahan, A, Mooren R, Bauer M, Kest B, Sarton E, Olofsen E. S(+)-ketamine Effect on Experimental Pain and Cardiac Output: A Population Pharmacokinetic-Pharmacodynamic Modeling Study in Healthy Volunteers. Anesthesiology. Anesthesiology 111:892-903. [abstract / full text]

Wesseldijk F, van Toorenenbergen AW, Gerth van Wijk G, Huygen
FJ, Zijlstra FJ (2008). IgE-Mediated Hypersensitivity: Patients with Complex Regional Pain Syndrome Type 1 (CRPS1) vs the Dutch Population. A Retrospective Study. Pain Medicine 10:172-178. [abstract / full text]

Zimmerman PH, Bolhuis JE, Willemsen A, Meyer ES, Noldus LPJJ. The Observer XT: A tool for the integrateion and synchronization of multimodal signals. Behav Res Methods 2009, 41:731-735.
[abstract / full text]

2008

Brunner F, Bachmann LM, Weber U, Kessels AG, Perez RS, Marinus J, Kissling R. Complex Regional Pain Syndrome 1 – the Swiss Cohort Study. BMC Musculoskelet Disord 2008, 9:92. [Abstract / Full text]

Collins, S, Hilten JJ van, Marinus J, Zuurmond WW, Lange JJ de, en Perez RS. Development of a symptoms questionnaire for Complex Regional Pain Syndrome and potentially related illnesses: the Trauma Related Neuronal Dysfunction Symptoms Inventory. Archives of Physical Medicine and Rehabilitation, 89:1114-1120. [Abstract / Full text]

Gieteling EW, van Rijn MA, de Jong BM, Hoogduin JM, Renken R, van Hilten JJ, Leenders KL. Cerebral Activation during Motor Imagery in Complex Regional Pain Syndrome type 1 with Dystonia. Pain 134:302-309. [Abstract / Full text]

Groeneweg JG, Heijmans-Antonissen C, Huygen FJPM, Zijlstra FJ. Expression of Endothelial Nitric Oxide Synthase and Endothelin-1 in Skin Tissue from Amputated Limbs of Patients with Complex Regional Pain Syndrome. Mediators of Inflammation Volume 2008, Article ID 680981, 5 pages. [Abstract / Full text]

Groeneweg G, Huygen FJPM, Niehof SP, Wesseldijk F, Bussmann JBJ, Schasfoort FC, Stronks DL, Zijlstra FJ. Effect of tadalafil on blood flow, pain, and function in chronic cold Complex Regional Pain Syndrome: a randomized controlled trial. BMC Musculoskeletal Disorder, 2008(9):143. [Abstract / Full text]

Groeneweg JG, Niehof S, Wesseldijk F, Huygen FJPM, Zijlstra FJ. Vasodilative Effect of Isosorbide Dinitrate Ointment in Complex Regional Pain Syndrome Type 1. Clinical Journal of Pain, 24:89-92. [abstract / full text]

de Mos, M, Huygen, FJPM, Dieleman JP, Koopman, JSHA, Stricker, BH, Sturkenboom, MCJM. Medical history and the onset of Complex Regional Pain Syndrome. Pain 139:458-466. [Abstract / Full text]

Moseley GL, Zalucki L, Birklein F, Marinus J, Van Hilten JJ, Luomajoki H. Thinking about movement hurts: The effect of motor imagery on pain and swelling in people with chronic arm pain. Arthritis Care & Research 2008, 59:623-631. [Abstract / Full text]

Munts AG, Van Rootselaar AF, Van der Meer JN, Koelman JHTM, Van Hilten JJ, Tijssen MAJ. Clinical and neurophysiological characterization of myoclonus in complex regional pain syndrome. Movement Disorders 2008, 23:581-587. [Abstract / Full text]

Munts AG, Zijlstra FJ, Nibbering PH, Daha MR, Marinus J, Dahan A, Hilten van JJ. Analysis of cerebrospinal fluid inflammatory mediators in chronic complex regional pain syndrome related dystonia. Clinical Journal of Pain, 24:30-34. [Abstract / Full text]

Niehof SP, Beerthuizen A, Huygen FJPM, Zijlstra FJ. Using Skin Surface Temperature to Differentiate Between Complex Regional Pain Syndrome Type 1 Patients After a Fracture and Control Patients with Various Complaints After a Fracture. Anesthesia & Analgesia, 106:270-277.

Perez RSGM, Pragt E, Geurts J, Zuurmond WWA, Patijn J, van Kleef M. Treatment of patients with complex regional pain syndrome type I with mannitol: a prospective, randomized, placebo-controlled, double-blind study. Journal of Pain 9:678-686. [Abstract / Full text]

Reedijk WB, van Rijn AM, Roelofs K, Tuijl JP, Marinus J, van Hilten JJ. Psychological Features of Patients with Complex Regional Pain Syndrome Type I Related Dystonia. Movement Disorders 23:1551-1559. [Abstract / Full text]

Schouten AC, Mugge W, Van der Helm FCT. NMClab, a model to assess the contributions of muscle visco-elasticity and afferent feedback to joint dynamics. Journal of Biomechanics 41:1659–1667. [Abstract / Full text]

Schouten AC, de Vlugt E, van Hilten JJ, van der Helm FCT. Quantifying proprioceptive reflexes during position control of the human arm. IEEE trans Biomed Eng, 2008, 55:311-321. [Abstract / Full text]

Schouten AC, de Vlugt E, van der Helm FCT. Design of perturbation signals for the estimation of proprioceptive reflexes. IEEE Trans Biomed Eng 2008, 55:1612-1619. [Abstract / Full text]

Sigtermans M, Looijestijn J, Olofsen E, Dahan A. Pulse Transit Time (PTT) Measurements During Laparoscopic and Open Abdominal Surgery: A Pilot Study in ASA I-II Female Patients. The Open Anesthesiology Journal, 2008, 2:20-25. [Abstract / Full text]

Wesseldijk F, Fekkes D, Huygen FJ, Bogaerts-Taal E en Zijlstra FJ. Increased plasma serotonin in Complex Regional Pain Syndrome type I. Anesthesia and Analgesia, 106(6): 1862-1867. [Abstract / Full text]

Wesseldijk F, Fekkes D, Huygen FJPM, Van de Heide-Mulder M, Zijlstra FJ. Increased plasma glutamate, glycine, and arginine levels in complex regional pain syndrome type 1. Acta Anaesthesiol Scand 2008, 52:688-694. [Abstract / Full text]

Wesseldijk F, Huygen FJ, Heijmans-Antonissen C, Niehof SP, Zijlstra FJ (2008). Six Years Follow-up of the Levels of TNF-α and IL-6 in Patients with Complex Regional Pain Syndrome Type 1. Mediators Inflamm Volume 2008, Article ID 469439, 7 pages. [Abstract / Full text]

Wesseldijk F, Huygen FJPM, Heijmans-Antonissen, C, Niehof SP en Zijlstra FJ. Tumor necrosis factor-α and interleukin 6 are not correlated with the characteristics of Complex Regional Pain Syndrome type I in 66 patients. European Journal of Pain, 12: 716-721. [Abstract / Full text]

Perez RSGM, Giezeman MJMM. Measurement instruments for CRPS. In: Wittink & Carr (Eds.) (2008). Pain Research and Clinical management: Pain management; evidence, outcomes and quality of life. A source book. Elsevier, Edinburgh, 2008; 215-238. (Book chapter)

Mos, M. de (2008). In search for the Etiology of the Complex Regional Pain Syndrome. Rotterdam: Erasmus Universiteit (PhD thesis)

Wesseldijk, F. (2008). Inflammatory soup: mediators of inflammation in CRPS. Rotterdam: Erasmus Universiteit (PhD thesis)

2007

van Hilten JJ, Geraedts EJ, Marinus J. Peripheral trauma and movement disorders. Parkinsonism and Related Disorders 2007, 13:395-399. [Abstract / Full text]

De Klaver MJM, Van Rijn MA, Marinus J, Soede W, de Laat, JAPM, Van Hilten JJ. Hyperacusis in patients with Complex Regional Pain Syndrome related dystonia. J Neurol Neurosurg Psychiatry 2007, 78:1310-3. [Abstract / Full text]

Kool J, Reubsaet L, Wesseldijk F, Maravilha RT, Pinkse MW, D’Santos CS, Hilten van JJ, Zijlstra FJ, Heck AJR. Suction blister fluid as potential body fluid for biomarker proteins. Proteomics 2007, 7:3638-3650. [Abstract / Full text]

Niehof SP, Huygen FJ, Stronks DL, Klein J, Zijlstra FJ. Reliability of observer assessment of thermographic images in complex regional pain syndrome type 1. Acta Orthopaedica Belgica 2007, 73:31-37. [Abstract / Full text]

de Mos M, De Bruijn AGJ, Huygen FJPM, Dieleman JP, Stricker BHC, Sturkenboom MCJM. The incidence of complex regional pain syndrome: A population-based study. Pain 2007, 129:12-20. [Abstract / Full text]

Perez RSGM, Collins S, Marinus J, Zuurmond WWA, de Lange JJ (2007). Diagnostic criteria for CRPS I: differences between patient profiles using 3 different diagnostic sets. European Journal of Pain 2007, 8:895-902. [Abstract / Full text]

Van Rijn MA, Marinus J, Putter H, Van Hilten JJ (2007). Onset and progression of dystonia in Complex Regional Pain Syndrome. Pain 2007, 130:287-293. [Abstract / Full text]

Stienen AHA, Schouten AC, Schuurmans J, van der Helm FCT (2007). Analysis of reflex modulation with a biologically realistic neural network. Journal of Computer Neuroscience, 23: 333-348. [Abstract / Full text]

Marinus J, van Hilten JJ. Clinimetrics and movement disorders. In Wolter ECh, van Laar T, Berendse HW (2007). Parkinsonism and Related Disorders. Amsterdam: VU University Press. (Book chapter)

Niehof S. (2007). Video thermography: complex regional pain syndrome in the picture. Rotterdam: Erasmus Universiteit. (PhD thesis).

2006

Groeneweg JG, Huygen FJPM, Heijmans-Antonissen C, Niehof S, Zijlstra FJ. Increased endothelin-1 and diminished nitric oxide levels in blister fluids of patients with intermediate cold type complex regional pain syndrome type. BMC Musculoskelet Disord 2006, 7:91. [abstract / full text]

Heijmans-Antonissen C, Wesseldijk F, Munnikes RJM, Huygen FJPM, Van der Meijden P, Hop WCJ ,Hooijkaas H, Zijlstra FJ. Multiplex Bead Array Assay for Detection of 25 Soluble Cytokines in Blister Fluid of Patients with Complex Regional Pain Syndrome Type 1. Mediators of Inflammation 2006:1–8. [abstract / full text]

van Hilten JJ. How do movement disorders fit in the syndrome of CRPS? Journal of Neutopathic Pain & Symptom Palliation 2006, 28:351-362. [abstract / full text]

Marinus J, Van Hilten JJ. Clinical expression profiles of Complex Regional Pain Syndrome, Fibromyalgia and a-specific Repetitive Strain Injury: More common denominators than pain?
Disability and Rehabilitation 2006, 28:351–362. [abstract / full text]

Niehof SP, Huygen FJPM, Van der Weerd RWP, Westra1 M, Zijlstra FJ. Thermography imaging during static and controlled thermoregulation in complex regional pain syndrome type 1: diagnostic value and involvement of the central sympathetic system. BioMedical Engineering OnLine 2006, 5:30. [abstract / full text]

Perez RSGM (2006). Defining pain. Disability and Rehabilitation 2006, 28:339–341.

Schouten AC, De Vlugt E, Van Hilten JJ, Van der Helm FCT. Design of a torque-controlled manipulator to analyse the admittance of the wrist joint. Journal of Neuroscience Methods 154:134–141. [abstract / full text]

De Vlugt E, Schouten AC, Van der Helm FCT. Quantification of intrinsic and reflexive properties during multijoint arm posture. Journal of Neuroscience Methods 2006, 155:328–349. [abstract / full text]

2005

Alexander GM, van Rijn MA, van Hilten JJ, Perreault MJ, Schwartzman RJ. Changes in cerebrospinal fluid levels of pro-inflammatory cytokines in CRPS. Pain 2005, 116:213-219. [abstract / full text]

Munnikes RJ, Muis C, Boersma M, Heijmans-Antonissen C, Zijlstra FJ, Huygen FJPM. Intermediate stage complex regional pain syndrome type 1 is unrelated to proinflammatory cytokines.
Mediators Inflamm 2005, 6:366-372. [abstract / full text]

Perez RSGM, Keijzer C, Bezemer PD, Zuurmond WWA, De Lange JJ. Predictive value of symptom level measurements for Complex Regional Pain Syndrome type I. Eur J Pain 2005, 9:49-56. [abstract / full text]

Perez RSGM, Burm PET, Zuurmond WWA, Bezemer PD, Brink HEJ, De Lange JJ. Physicians’ assessments versus measured symptoms of Complex Regional Pain Syndrome type 1 (RSD): presence and severity. Clin J Pain 2005, 21:272-276. [abstract / full text]

Roorda LD, Molenaar IW, Lankhorst GJ, Bouter LM and the measuring Mobility Study Group (o.a. Perez RSGM). Improvement of a questionnaire measuring activity limitations in rising and sitting down in patients with lower-extremity disorders living at home. Arch Phys Med Rehabil 2005, 86:2204-2210. [abstract / full text]

Roorda LD, Roebroeck ME, Van Tilburg T, Molenaar IW, Lankhorst GJ, Bouter LM and the measuring Mobility Study Group (o.a. Perez RSGM). Measuring activity limitations in walking: development of a hierarchical scale for patients with lower-extremity disorders who live at home. Arch Phys Med Rehabil 2005, 86:2277-2283. [abstract / full text]

2004

Huygen FJPM, Ramdhani N, Toorenenberg van A, Klein J, Zijlstra FJ. Mast cells are involved in inflammatory reactions during Complex Regional Pain Syndrome type 1. Immunology letters 2004, 91:147-154. [abstract / full text]

Huygen FJPM, Hagen van M, Dalen van P, Niehof S, Zijlstra FJ. Succesful treatment of CRPS1 with anti TNF. The Journal of Pain and Symptom Management 2004, 27:101-103. [abstract / full text]

Huygen FJPM, Niehof S, Klein J, Zijlstra FJ. Computer assisted skin videothermography is a highly sensitive tool in the diagnosis and monitoring of complex regional pain syndrome type 1. The european journal of applied physiology 2004, 19:516-524. [abstract / full text]

Roorda LD, Roebroeck ME, Van Tilburg T, Lankhorst GJ, Bouter LM and the measuring Mobility Study Group (o.a. Perez RSGM). Measuring activity limitations in climbing stairs: development of a hierarchical scale for patients with lower extremity disorders living at home. Arch Phys Med Rehabil 2004, 85:967-971. [abstract / full text]