1.09.08 - Treatment of CRPS with Mannitol not effective
The treatment of CPRS with mannitol has not proved effective. That is the conclusion of a study done by Perez and others at the VU Medical Centre in Amsterdam. The aim of the study was to assess the possible effects of intravenous administration of mannitol on the inflammatory processes of CRPS.
An inflammatory reaction is thought to play a role in some of the clinical features of CRPS, like red skin, elevated skin temperature and swelling. The intravenous administration of mannitol might diminish the inflammation.
The administration of mannitol did not have a better effect that a placebo. This treatment does not improve present treatments of CRPS.
The results of this study have recently been published in the Journal of Pain:
Perez, R.S., E. Pragt, J. Geurts, W.W. Zuurmond, J. Patijn en M. van Kleef (2008). Treatment of patients with complex regional pain syndrome type I with Mannitol: a prospective, randomised placebo-controlled, double blind study. Journal of Pain, 9:678-686.