TREND (Trauma RElated Neuronal Dysfunction) is a consortium of Dutch medical and technical universities and industrial companies, in which the research on Complex Regional Pain Syndrome type 1 (CRPS-1) is integrated.

News overview

26.07.10 - Validation of the "Budapest Criteria"
Norman Harden and others did a study in order to compare current IASP criteria for CRPS to new diagnostic criteria (the "Budapest Criteria"). The results are published in the Journal of the International Association for the Study of Pain.
Read more
21.07.10 - Baclofen-induced chorea in CRPS-related dystonia
A study on the use of intrathecal administration of baclofen shows that CRPS patients develop baclofen-induced chorea.
Read more
1.07.10 - World Congress of Pain in Montreal
From 29 August until 2 September the World Congress of Pain will be held in Montreal, Canada. Various TREND researchers will attend this congress to speak about their research on CRPS.
Read more
15.06.10 - No genetic mutations found for dystonia
Gosso and colleagues (LUMC, Leiden) found no genetic mutations in CRPS patients with dystonia. The research findings were recently published in Journal of Neurology
Read more
25.05.10 - Spontaneous onset of CRPS

CRPS is usually preceded by a trauma like a fracture, inflammation or operation. In 3-11% of all cases however the disease develops spontaneously. De Rooij and others (LUMC Leiden) compared ‘spontaneous’ CRPS patients with trauma related CRPS patients. The results have recently been published in the European Journal of Pain.

Read more
22.04.10 - Doctoral degree A.M. de Rooij
On Tuesday 27 April Annetje de Rooij will take her doctoral degree at Leiden University by defending her thesis Genetic and epidemiological aspects of Complex Regional Pain Syndrome.
Read more
19.04.10 - Feedback van lichaam speelt rol bij beweging
Verschillende systemen spelen een rol bij het vrijwillig uitvoeren van fysieke taken. Mugge en anderen (TU Delft) onderzochten of de bijdrage van ieder van deze systemen is te kwantificeren. De resultaten zijn onlangs verschenen in Experimental Brain Research.
Read more
14.04.10 - Brush-evoked allodynia predicts outcome of spinal cord stimulation in CRPS
Van Eijs and others (Acacemic Hospital Maastricht) did a study in order to predict in which cases SCS can be used against CRPS.
The results were published in the European Journal of Pain.
Read more
6.04.10 - TREND symposium 2010
On Friday 26 March the yearly TREND symposium was held in Zeist. During this symposium 10 research trainees presented findings from completed studies or research proposals. Futhermore there was a presentation by Florian Brunner, from the Swiss TREND partner, Balgrist Uniklinik in Zürich.
Read more
1.02.10 - Ketamine leads to pain reduction

The standard treatments of pain in CRPS ltaten op. Sigtermans and others studied the effect of S(+)-ketamine on pain reduction in CRPS. The results were recently published in Pain.

Read more

26.01.10 - Referral and treatment not always as planned

CRPS patients are treated by various medical specialists. De Mos and others (Erasmus MC Rotterdam) did a study on the way patients are referred and treated in the Netherlands. The findings have recently been published in Acta Anaesthesiologica Scandinavica .

The Dutch guidellines state that CRPS should be treated by ‘free radical scavengers’ in combination with non-invasive therapy. Only half of 102 patients in this study said they had received these ‘scavengers’ in the first 3 months of their treatment.

Because 2 out of every 3 patients first went to their general practitioners, they should be encouraged to start treatment and follow the guidelines.

Title: Referral and treatment patterns for complex regional pain syndrome in the Netherlands
Authors: de Mos M, Huygen FJPM, Stricker BHCh, Dieleman JP, Sturkenboom MCJM
In: Acta Anaesthesiologica Scandinavica 53:816-825.
Read full text article