1.06.11 - PhD Thesis of Winfred Mugge: Reflex mechanisms in CRPS-related dystonia
On Wednesday 22th of June at 15.00h, Winfred Mugge will defend his PhD thesis “Reflex mechanisms in CRPS-related dystonia” at Delft University of Technology. The promotors are: prof. dr. F.C.T. van der Helm (TU Delft) en prof. dr. J.J. van Hilten (Leiden) and copromotor is dr. ir. A.C. Schouten.
This thesis describes research within TREND that focuses on the cause of CRPS-related dystonia from an engineering point of view:
Approximately 25% of the patients with CRPS develop fixed dystonia, a movement disorder associated with sustained muscle contractions that result in abnormal postures. Although the mechanisms behind fixed dystonia are still elusive, the evidence implicating involvement of aberrant regulation of muscle force is compelling.
In the research of Winfred Mugge a neuromuscular model with aberrant regulation of muscle force successfully mimicked fixed dystonia, while experiments demonstrated involvement of muscle force regulation in fixed dystonia.
The PhD thesis of Winfred mugge has been accepted by the repository of Delft University of Technology.