TREND (Trauma RElated Neuronal Dysfunction) is a consortium of Dutch medical and technical universities and industrial companies, in which the research on Complex Regional Pain Syndrome type 1 (CRPS-1) is integrated.

News overview

26.07.10 - Validation of the "Budapest Criteria"
Norman Harden and others did a study in order to compare current IASP criteria for CRPS to new diagnostic criteria (the "Budapest Criteria"). The results are published in the Journal of the International Association for the Study of Pain.
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21.07.10 - Baclofen-induced chorea in CRPS-related dystonia
A study on the use of intrathecal administration of baclofen shows that CRPS patients develop baclofen-induced chorea.
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1.07.10 - World Congress of Pain in Montreal
From 29 August until 2 September the World Congress of Pain will be held in Montreal, Canada. Various TREND researchers will attend this congress to speak about their research on CRPS.
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15.06.10 - No genetic mutations found for dystonia
Gosso and colleagues (LUMC, Leiden) found no genetic mutations in CRPS patients with dystonia. The research findings were recently published in Journal of Neurology
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25.05.10 - Spontaneous onset of CRPS

CRPS is usually preceded by a trauma like a fracture, inflammation or operation. In 3-11% of all cases however the disease develops spontaneously. De Rooij and others (LUMC Leiden) compared ‘spontaneous’ CRPS patients with trauma related CRPS patients. The results have recently been published in the European Journal of Pain.

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22.04.10 - Doctoral degree A.M. de Rooij
On Tuesday 27 April Annetje de Rooij will take her doctoral degree at Leiden University by defending her thesis Genetic and epidemiological aspects of Complex Regional Pain Syndrome.
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19.04.10 - Feedback van lichaam speelt rol bij beweging
Verschillende systemen spelen een rol bij het vrijwillig uitvoeren van fysieke taken. Mugge en anderen (TU Delft) onderzochten of de bijdrage van ieder van deze systemen is te kwantificeren. De resultaten zijn onlangs verschenen in Experimental Brain Research.
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14.04.10 - Brush-evoked allodynia predicts outcome of spinal cord stimulation in CRPS
Van Eijs and others (Acacemic Hospital Maastricht) did a study in order to predict in which cases SCS can be used against CRPS.
The results were published in the European Journal of Pain.
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6.04.10 - TREND symposium 2010
On Friday 26 March the yearly TREND symposium was held in Zeist. During this symposium 10 research trainees presented findings from completed studies or research proposals. Futhermore there was a presentation by Florian Brunner, from the Swiss TREND partner, Balgrist Uniklinik in Zürich.
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1.02.10 - Ketamine leads to pain reduction

The standard treatments of pain in CRPS ltaten op. Sigtermans and others studied the effect of S(+)-ketamine on pain reduction in CRPS. The results were recently published in Pain.

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1.02.10 - Ketamine leads to pain reduction

The standard treatments of pain in CRPS are not succesful for every patient. Sigtermans and others studied the effect of S(+)-ketamine on pain reduction in CRPS. The results were recently published in Pain.

For a few days 30 CRPS patients received Ketamine. This resulted in pain scores that were significantly lower than those of the patients in the control group. However, this effect disappeared after 12 weeks and no improvement in physical functions was found. On the positive side, the patients themselves considered the side effects to be acceptable.

Title: Ketamine produces effective and long-term pain relief in patients with Complex Regional Pain Syndrome Type 1
Authors: Sigtermans MJ, Van Hilten JJ, Bauer MCR, Arbous MS, Marinus J, Sarton EY, Dahan A
In: Pain 145:304-311
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