TREND (Trauma RElated Neuronal Dysfunction) is a consortium of Dutch medical and technical universities and industrial companies, in which the research on Complex Regional Pain Syndrome type 1 (CRPS-1) is integrated.

News overview

26.07.10 - Validation of the "Budapest Criteria"
Norman Harden and others did a study in order to compare current IASP criteria for CRPS to new diagnostic criteria (the "Budapest Criteria"). The results are published in the Journal of the International Association for the Study of Pain.
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21.07.10 - Baclofen-induced chorea in CRPS-related dystonia
A study on the use of intrathecal administration of baclofen shows that CRPS patients develop baclofen-induced chorea.
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1.07.10 - World Congress of Pain in Montreal
From 29 August until 2 September the World Congress of Pain will be held in Montreal, Canada. Various TREND researchers will attend this congress to speak about their research on CRPS.
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15.06.10 - No genetic mutations found for dystonia
Gosso and colleagues (LUMC, Leiden) found no genetic mutations in CRPS patients with dystonia. The research findings were recently published in Journal of Neurology
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25.05.10 - Spontaneous onset of CRPS

CRPS is usually preceded by a trauma like a fracture, inflammation or operation. In 3-11% of all cases however the disease develops spontaneously. De Rooij and others (LUMC Leiden) compared ‘spontaneous’ CRPS patients with trauma related CRPS patients. The results have recently been published in the European Journal of Pain.

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22.04.10 - Doctoral degree A.M. de Rooij
On Tuesday 27 April Annetje de Rooij will take her doctoral degree at Leiden University by defending her thesis Genetic and epidemiological aspects of Complex Regional Pain Syndrome.
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19.04.10 - Feedback van lichaam speelt rol bij beweging
Verschillende systemen spelen een rol bij het vrijwillig uitvoeren van fysieke taken. Mugge en anderen (TU Delft) onderzochten of de bijdrage van ieder van deze systemen is te kwantificeren. De resultaten zijn onlangs verschenen in Experimental Brain Research.
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14.04.10 - Brush-evoked allodynia predicts outcome of spinal cord stimulation in CRPS
Van Eijs and others (Acacemic Hospital Maastricht) did a study in order to predict in which cases SCS can be used against CRPS.
The results were published in the European Journal of Pain.
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6.04.10 - TREND symposium 2010
On Friday 26 March the yearly TREND symposium was held in Zeist. During this symposium 10 research trainees presented findings from completed studies or research proposals. Futhermore there was a presentation by Florian Brunner, from the Swiss TREND partner, Balgrist Uniklinik in Zürich.
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1.02.10 - Ketamine leads to pain reduction

The standard treatments of pain in CRPS ltaten op. Sigtermans and others studied the effect of S(+)-ketamine on pain reduction in CRPS. The results were recently published in Pain.

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8.01.10 - Only very small increased risk in siblings of CRPS patients

If genetic factors play a role in a disease, it could mean that siblings of patients have an increased risk of developing that disease compared to the general population. This has not been studied before for Complex Regional Pain Syndrome (CRPS).

De Rooij and others asked 405 CRPS patients about the occurence of CRPS in their siblings. The aim of the study was to assess the sibling recurrence risk. The results of this study showed that there was no elevated risk for the entire group. The risk for the group under the age of 50 was increased however. Because the risk of developing the disease in that age group is relatively small, siblings of CRPS patients do not need to worry.

The results of this research have recently been published.

Title: Increased risk of Complex Regional Pain Syndrome in siblings of patients?
Authors: de Rooij AM, de Mos M, van Hilten JJ, Sturkenboom MCJM, Gosso MF, van den Maagdenberg AMJM, Marinus J.
In: Journal of Pain
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