TREND (Trauma RElated Neuronal Dysfunction) is a consortium of Dutch medical and technical universities and industrial companies, in which the research on Complex Regional Pain Syndrome type 1 (CRPS-1) is integrated.

News overview

27.08.10 - Single bolus administration of ITM not efficacious in CRPS patients
A double-blind experiment aimed to investigate the efficacy and safety of a single intrathecal administration of methylprednisolone (ITM) in patients with complex regional pain syndrome. ITM had no effect on pain.
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4.08.10 - New research findings on the influence of the NEP gene on CRPS
The NEP gene is not a major risk factor for CRPS.
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26.07.10 - Validation of the "Budapest Criteria"
Norman Harden and others did a study in order to compare current IASP criteria for CRPS to new diagnostic criteria (the "Budapest Criteria"). The results are published in Pain.
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21.07.10 - Baclofen-induced chorea in CRPS-related dystonia
A study on the use of intrathecal administration of baclofen shows that CRPS patients develop baclofen-induced chorea.
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1.07.10 - World Congress of Pain in Montreal
From 29 August until 2 September the World Congress of Pain will be held in Montreal, Canada. Various TREND researchers will attend this congress to speak about their research on CRPS.
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15.06.10 - No genetic mutations found for dystonia
Gosso and colleagues (LUMC, Leiden) found no genetic mutations in CRPS patients with dystonia. The research findings were recently published in Journal of Neurology
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25.05.10 - Spontaneous onset of CRPS

CRPS is usually preceded by a trauma like a fracture, inflammation or operation. In 3-11% of all cases however the disease develops spontaneously. De Rooij and others (LUMC Leiden) compared ‘spontaneous’ CRPS patients with trauma related CRPS patients. The results have recently been published in the European Journal of Pain.

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22.04.10 - Doctoral degree A.M. de Rooij
On Tuesday 27 April Annetje de Rooij will take her doctoral degree at Leiden University by defending her thesis Genetic and epidemiological aspects of Complex Regional Pain Syndrome.
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19.04.10 - Feedback van lichaam speelt rol bij beweging
Verschillende systemen spelen een rol bij het vrijwillig uitvoeren van fysieke taken. Mugge en anderen (TU Delft) onderzochten of de bijdrage van ieder van deze systemen is te kwantificeren. De resultaten zijn onlangs verschenen in Experimental Brain Research.
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14.04.10 - Brush-evoked allodynia predicts outcome of spinal cord stimulation in CRPS
Van Eijs and others (Acacemic Hospital Maastricht) did a study in order to predict in which cases SCS can be used against CRPS.
The results were published in the European Journal of Pain.
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14.04.10 - Brush-evoked allodynia predicts outcome of spinal cord stimulation in CRPS

Spinal cord stimulation has proven to be an effective method for treating CRPS, but it is an invasive and rather expensive therapy.
Furthermore, about a third of the patients treated with SCS do not show improvents and about 32-38% of all patients experience complications.

Van Eijs and others (Acacemic Hospital Maastricht) did a study in order to predict in which cases SCS can be used against CRPS.
The results were published in the European Journal of Pain.

Based on this study Van Eijs and colleagues concluded that brush-evoked allodynia may be a significant negative prognostic factor of SCS treatment outcome after 1 year in chronic CRPS-1

Van Eijs F, Smits H, Geurts J, Kessels A, Kemler M, van Kleef M, Joosten E, Faber C: Brush-evoked allodynia predicts outcome of spinal cord stimulation in Complex Regional Pain Syndrome type 1. Eur J Pain. 2010 Feb;14(2):164-9. [Full text]